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Registros recuperados: 6
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Evaluation of potential embryo toxicity of albendazole sulphoxide in CF1 mice Biocell
Teruel,Miriam; D'Ercole,Jaqueline; Catalano,Rodolfo.
Benzimidazole compounds are used in both humans and animals for controlling helminth parasites. Albendazole has teratogenic effects attributed to its active metabolite albendazole sulphoxide. The aim of this work was to evaluate the effect of the latter compound when administered to pregnant CF1 mice during the preimplantation period. Females were superovulated by intraperitoneal injection of 10 IU of eCG and 10 IU of hCG (48h later) and were paired with males of proven fertility. Albendazole sulphoxide (200 mg/kg) was orally administered by gavages at day 1, 2 or 3 of pregnancy; the control group received only the vehicle (carboxymethylcellulose). Females were killed by cervical dislocation at day 4 of pregnancy and embryos were flushed from uteri with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Benzimidazole; Early pregnancy; Developmental exposure.
Ano: 2011 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452011000100004
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Gene Expressions in the Persistent Corpus Luteum of Postpartum Dairy Cows: Distinct Profiles from the Corpora Lutea of the Estrous Cycle and Pregnancy OAK
MAGATA, Fumie; SHIRASUNA, Koumei; STRÜVE, Klaas; HERZOG, Kathrin; SHIMIZU, Takashi; BOLLWEIN, Heinrich; MIYAMOTO, Akio; 清水, 隆; 宮本, 明夫.
Persistence of the corpus luteum (CL) in cattle usually occurs during the puerperium and is associated with interference of prostaglandin (PG) F2α release from the uterus. The objective of the present study was to determine for the first time the gene expressions in the persistent CL compared with the CL of pregnancy and cyclic CL. Three types of CL biopsy samples were collected from 32 lactating Holstein cows: (1) CL persisting for 29 to 33 days after the first ovulation postpartum (persistent CL, n=9), (2) CL between days 29 and 33 of early pregnancy (CL of pregnancy, n=8) and (3) CL between days 10 and 13 of the estrous cycle (cyclic CL, n=27). mRNA expression of 2',5'-oligoadenylate synthetase-1 was upregulated only in the CL of pregnancy, confirming...
Palavras-chave: Dairy cow; Early pregnancy; Persistent corpus luteum; MRNA expression.
Ano: 2012 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3938
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Generalized linear mixed models for the genetic evaluation of binary reproductive traits: a simulation study R. Bras. Zootec.
Garcia,Diogo Anastácio; Pereira,Idalmo Garcia; Fonseca e Silva,Fabyano; Rosa,Guilherme Jordão de Magalhães; Pires,Aldrin Vieira; Leandro,Roseli Aparecida.
The objective of this study was to evaluate the use of probit and logit link functions for the genetic evaluation of early pregnancy using simulated data. The following simulation/analysis structures were constructed: logit/logit, logit/probit, probit/logit, and probit/probit. The percentages of precocious females were 5, 10, 15, 20, 25 and 30% and were adjusted based on a change in the mean of the latent variable. The parametric heritability (h²) was 0.40. Simulation and genetic evaluation were implemented in the R software. Heritability estimates (ĥ²) were compared with h² using the mean squared error. Pearson correlations between predicted and true breeding values and the percentage of coincidence between true and predicted ranking, considering the 10%...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Beef cattle; Early pregnancy; Genetic parameters; GLMM; Link function.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982012000100008
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Genetic and environmental effects on sexual precocity traits in Nellore cattle R. Bras. Zootec.
Meirelles,Sarah Laguna; Espasandin,Ana Carolina; Mattar,Maira; Queiroz,Sandra Aidar de.
The objective of this study was to estimate the heritability of probability of early pregnancy (PEP) and scrotal circumference (SC) and the genetic correlation between these traits in Nellore cattle. PEP records from 11,696 Nellore females born between 1983 and 2001 were analyzed. PEP was assumed to be one for females that effectively bred in the herd (19.84%) and zero for those discarded before first calving (80.16%). The model used to study PEP included the effects of contemporary group, age of dam at calving and heifer weaning age, direct additive genetic effects, and residual effects. For SC, 9335 records were analyzed considering the effect of contemporary group, direct additive genetic effects and residual effects. Covariance components were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Beef cattle; Early pregnancy; Scrotal circumference; Threshold trait.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982009000800012
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Upregulation of interferon-stimulated genes and interleukin-10 in peripheral blood immune cells during early pregnancy in dairy cows. OAK
MAGATA, Fumie; SHIRASUNA, Koumei; STRÜVE, Klaas; HERZOG, Kathrin; SHIMIZU, Takashi; BOLLWEIN, Heinrich; MIYAMOTO, Akio; 清水, 隆; 宮本, 明夫.
Persistence of the corpus luteum (CL) in cattle usually occurs during the puerperium and is associated with interference of prostaglandin (PG) F2α release from the uterus. The objective of the present study was to determine for the first time the gene expressions in the persistent CL compared with the CL of pregnancy and cyclic CL. Three types of CL biopsy samples were collected from 32 lactating Holstein cows: (1) CL persisting for 29 to 33 days after the first ovulation postpartum (persistent CL, n=9), (2) CL between days 29 and 33 of early pregnancy (CL of pregnancy, n=8) and (3) CL between days 10 and 13 of the estrous cycle (cyclic CL, n=27). mRNA expression of 2',5'-oligoadenylate synthetase-1 was upregulated only in the CL of pregnancy, confirming...
Palavras-chave: Dairy cow; Early pregnancy; Persistent corpus luteum; MRNA expression.
Ano: 2012 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4039
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Vascular Changes in the Corpus Luteum During Early pregnancy in the Cow OAK
BEINDORFF, Nicola; NAGAI, Kaya; SHIRASUNA, Koumei; HERZOG, Kathrin; HOEFFMANN, Katharina; SASAKI, Motoki; BOLLWEIN, Heinrich; MIYAMOTO, Akio; 佐々木, 基樹; 宮本, 明夫; 白砂, 孔明.
The present study determined vascular changes in the bovine corpus luteum (CL) at Day 16 (early maternal recognition period) and Day 40 in early pregnancy and compared them to the CL from Day 12 and Day 16 of the estrous cycle. The CLs were analyzed in the central and peripheral regions, where site-depending features of vessels and angiogenic factors are evident. The same protein level of the endothelial cell marker von Willebrand factor was retained in the CL from Day 16 of the estrous cycle to Day 40 of early pregnancy. The protein level of pericytes and smooth muscle cells was determined using smooth muscle α-actin; the level decreased at Day 40 of early pregnancy in both regions of the CL. No significant change in the expressions of vascular...
Palavras-chave: Corpus luteum; Cow; Early pregnancy; Endothelial cells.
Ano: 2010 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2811
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